Di Ianni Lab

Transcranial ultrasound neuromodulation is a promising therapeutic tool for the noninvasive treatment of neuropsychiatric disorders. However, the expansive parameter space and difficulties in controlling for peripheral auditory confounds make it challenging to identify ultrasound sequences and brain targets with potential therapeutic efficacy. We develop miniaturized wearable ultrasound systems to enable high-throughput testing of brain targets and acoustic parameters in clinically relevant behavioral models. Our systems facilitate the design and clinical translation of ultrasound sequences for neurostimulation and targeted drug delivery.

See our paper here.

We use cutting-edge experimental modalities like whole-brain functional ultrasound imaging in freely behaving rodents, electrophysiology, and optical recordings to study the mechanism of action of drugs and other interventions relevant to the treatment of neuropsychiatric disorders. Ultimately, we aim to identify noninvasive and clinically translatable biomarkers to accelerate the development of closed-loop image-guided interventions.

See our publications about sex differences in the responses to racemic ketamine and S-ketamine reinforcing effects.

Functional ultrasound imaging (fUSI) is an exciting modality for whole-brain neuroimaging in freely behaving rodents. However, conventional fUSI implementations generate very large data throughputs, posing significant challenges for real-time processing and visualization. We develop deep learning methods for fUSI reconstruction that allow reducing the resources needed for data acquisition and processing by up to 95% while preserving the original image quality.

For further information, read the paper here. Code and test data sets are available here.